Genetic results are usually not returned to research participants in Uganda despite their increased demand. We report on researchers’ perceptions and experiences of return of individual genetic research results. The study involved 15 in-depth interviews of investigators involved in genetics and/or genomic research. A thematic approach was used to interpret the results. The four themes that emerged from the data were the need for return of individual results including incidental findings, community engagement and the consenting process, implications and challenges to (...) return of individual results. While researchers are willing to return clinically significant genetic results to research participants, they remain unsure of how this should be implemented. Suggestions to aid implementation of return of results included reconsenting of participants before receiving individual genetic results and increasing access to genetic counseling services. Community engagement to determine community perceptions and individual preferences for the return of results, and also prepare participants to safely receive results emerged as another way to support return of results. Researchers have a positive attitude toward the return of clinically significant genetic results to research participants. There is need to develop national guidance on genetic research and also build capacity for clinical genetics and genetic counseling. (shrink)

BackgroundFew studies have examined factors associated with willingness of people living with HIV to participate in HIV treatment clinical trials in Sub-Saharan Africa. We assessed the factors associated with participation of PLHIV in HIV treatment clinical trials research at a large urban clinical and research facility in Uganda.MethodsA mixed methods study was conducted at the Infectious Diseases Institute, adult HIV clinic between July 2016 and January 2017. Data were collected using structured questionnaires, focused group discussions with respondents categorised as either (...) participated or never participated in clinical trials and key informant interviews with IDI staff. A generalized linear model with a logit link function was used for multivariate analyses while the qualitative data were summarized using a thematic approach.ResultsWe enrolled a total of 202 and analysed 151 participants, 77 of whom were male with mean age of 41 years. The majority 127 expressed willingness to participate in treatment clinical trials if given an opportunity. At bivariate analysis, willingness to participate was significantly associated with respondents’ perception of a satisfactory compensation package, special status accorded and belief that their health status would improve while on the clinical trial. At multivariate analysis, a satisfactory compensation package and special status accorded in clinical trials remained significant. The qualitative data analysis confirmed these findings as participants valued the privilege of jumping the clinic waiting queues and spending less time in clinic, the wide range of free tests offered to trial participants, unrestricted access to senior physicians and regular communication from study team. Additionally, free meals offered during clinic visits meant that participants were not in a hurry to go back home. Barriers to participation included the perception that new drugs were being tested on them, fear of side effects like treatment failure and the uncertainty about privacy of their data.ConclusionWe found overwhelming willingness to participate in HIV treatment clinical trials. This was largely extrinsically influenced by the perceived material and health-related benefits. Investigators should pay attention to participants’ concerns for benefits which may override the need to understand study procedures and risks. (shrink)

BackgroundThe return of genetics and genomics research results has been a subject of ongoing global debate. Such feedback is ethically desirable to update participants on research findings particularly those deemed clinically significant. Although there is limited literature, debate continues in African on what constitutes appropriate practice regarding the return of results for genetics and genomics research. This study explored perspectives and ethical considerations of Ugandan genomics researchers regarding the return of genetics and genomics research results.MethodsThis was a qualitative study that (...) employed in-depth interviews. Thirty participants were purposively selected based on their expertise as genomics researchers in Uganda. Data were analysed through content analysis along the main themes of the study using a comprehensive thematic matrix, to identify common patterns arising from the narratives. NVivo software 12 was used to support data analysis.ResultsThe return of genetics and genomics research results was generally acceptable to researchers, and some indicated that they had previously returned individual or aggregate results to participants and communities. The main reasons cited for sharing research results with participants included their clinical utility, actionability and overall benefit to society. Ethical considerations for appropriate return of results included a need for effective community engagement, genetic counselling prior to disclosure of the results, adequate informed consent, and proper assessment of the implications of, or consequences of returning of results. However, the approaches to return of results were perceived as unstandardized due to the lack of appropriate regulatory frameworks.ConclusionsThe return of genetic and genomic research results is generally acceptable to researchers despite the lack of appropriate regulatory frameworks. Ethical considerations for return of genetics and genomics research results are highly divergent, hence the need for national ethical guidelines to appropriately regulate the practice. (shrink)

The ArgumentThis paper sets out a framework for understanding how the scientific community constructs computer simulation as an epistemically and pragmatically useful methodology. The framework is based on comparisons between simulation and the loosely-defined categories of “theoretical work” and “experimental work.” Within that framework, the epistemological adequacy of simulation arises from its role as a mathematical manipulation of a complex, abstract theoretical model. To establish that adequacy demands a detailed “theoretical” grasp of the internal structure of the computer program. Simultaneously, (...) the pragmatic usefulness of simulation arises from its role as a “virtual laboratory.” That role is made possible by black-boxing the internal structure of the program, such that the scientist can interact with the computer in an intuitive, “experimental” manner. Thus simulation is rendered authoritative, opening up encoded theories to a novel, “experimental” type of manipulation. (shrink)

This article argues that the fact that an action will compound a prior injustice counts as a reason against doing the action. I call this reason The Anti-Compounding Injustice principle or aci. Compounding injustice and the aci principle are likely to be relevant when analyzing the moral issues raised by “big data” and its combination with the computational power of machine learning and artificial intelligence. Past injustice can infect the data used in algorithmic decisions in two distinct ways. Sometimes prior (...) injustice undermines the accuracy of the data itself. In these contexts, improving accuracy will also help to avoid compounding injustice. Other times, past injustice produces real-world differences among people with regard to skills, health, wealth, and other traits that employers, lenders, and others seek to measure. When decisions are based on accurate data that itself results from prior injustice, these decisions can also compound injustice. This second dynamic has received less attention than the first but is especially important because improving the accuracy of data will not mitigate this unfairness. (shrink)

Exploring the philosophical foundations of discrimination law as it exists in several jurisdictions, this collection of all new essays bridges the gap between abstract philosophical work on justice and fairness and legal work on specific types of discrimination.

The Wilderness of Dreams: Exploring the Religious Meanings of Dreams in Modem Western Culture. Kelly Bulkeley. Albany: State University of New York Press, 1994. 309 pp. $19.95 (paper).

Philosophical aesthetics emerges out of eighteenth-century discussions of taste that paid scant attention to the experience of tasting and ingesting food. Sarah Worth diagnoses this historical oversight and offers an unexpected remedy. She argues that we should start our analysis of aesthetic taste over again, this time beginning with the pleasures of the tongue and mouth, and work out from there to consider the kinds of experience, knowledge, and appreciation that belong to eating and savoring. As she argues, our ability (...) to make gustatory discriminations and to determine what tastes good and why is not as different from our aesthetic judgments as philosophers and other aesthetic theorists might have led us to believe. In this engaging and readable book, Worth persuasively argues that food and its many tastes deserve serious philosophical consideration.Worth explores a number of puzzles that arise when we try to make sense of the concept of taste. She disentangles the metaphorical sense of taste understood as a reasoned judgment expressing aesthetic preferences from the literal sense of taste which involves our sensory experiences when food is in our mouths. She discusses good and bad taste, food and pleasure, authentic and inauthentic food, “food porn”—those impossibly glamourized images of food that we find in advertising and magazines and cookbooks and social media—and the role of recipes in the practice of cooking. She places our everyday experiences of food in the context of wider relationships and activities including cultivation, harvesting, processing, shipping, and purchasing, as well as the preparation and cooking meals for family and friends. The book is punctuated by many of the usual philosophical suspects (Plato and Aristotle, Hume and Kant, Bullough and Sibley) as well as critical and feminist theorists, food sociologists, and a number of famous chefs including Fannie Farmer, Julie Child, and Nigella Lawson. If Worth endorses a particular metaphilosophy of food, it would be that of the Slow Food movement, which is the subject of Chapter Three. (shrink)

This dissertation inquires into the interpretation of agents' actions and utterances, and into the role of narrative theory in that interpretation. My thesis is that psychological explanation is an agent-centred, narrative-based interpretive practice. Agent-centred interpretation takes the form of narrative because such interpretations are governed by the need to discover or impose an intelligible explanatory pattern on events involving others like ourselves. I argue that narrative form is not a secondary way of construing action, but is what enables us to (...) recognize the intelligibility of agents' actions. Thus it is a main task of the dissertation to draw attention to the poetical nature of interpretation, and to the auto-poetical nature of self-interpreting agents. Interpretation is in essence intersubjective and communicative, and is doubly committed to intelligibility, since it must not only make sense of an agent's action, but also show how that action could have made sense to her. Conceiving of interpretation as an example of intersubjective communication allows me to present a poetics of psychological explanation. Not only does such a poetics outline the formal constraints on the interpretation of agents and their actions; it also allows me to show that the constraints in question are narrative constraints. (shrink)

Willful blindness is not an appropriate substitute for knowledge in crimes that require a mens rea of knowledge because an actor who contrives his own ignorance is only sometimes as culpable as a knowing actor. This paper begins with the assumption that the classic willfully blind actor—the drug courier—is culpable. If so, any plausible account of willful blindness must provide criteria that find this actor culpable. This paper then offers two limiting cases: a criminal defense lawyer defending a client he (...) suspects of perjury and a pain doctor who suspects his patient may be lying about her pain. The paper argues that each of these actors is justified in cultivating ignorance about his client’s or patient’s truthfulness. If this is right, then a good theory of willful blindness must distinguish these cases. The article argues that neither Husak & Callender’s motivation-based account of willful blindness nor the recklessness account is able to do so. The paper proposes the following alternative: contrived ignorance constitutes culpable blindness when the decision to remain blind or to cultivate blindness is not itself justified. This Justification approach meshes with our intuitions about willfully blind drug couriers as well as willfully blind lawyers and doctors. (shrink)

Beyond “A Lecture on Ethics,” Wittgenstein says little on the topic of ethics, despite professing a great respect for ethics. I argue that while Wittgenstein ceases to speak of ethics, his account fits equally within his Tractarian and post-Tractarian writing. On both accounts of language, ethics remains nonsense, but it is not insignificant nonsense. However, because Wittgenstein holds ethics to concern absolute values that are in principle inexpressible, his anti-theoretical conception of ethics fails to offer guidance in how one ought (...) to live. That is, ethics ultimately cannot be show unless it can, in some sense, be said. (shrink)

A UN report, which comprehensively documents the advance of global population ageing, was released on 1 October 2012, the International Day of Older Persons. In the West, this development has been accelerated by and will be profoundly experienced by the baby boomers. As they reach ages historically linked with retirement their numbers are rising, as are expectations for annual age-related public spending. Vulnerabilities are regularly being exposed in terms of medical care, social care and inadequate retirement planning. This makes acceptance (...) of the traditional narrative for ageing, including passivity, complacency and accelerating dependency, patently unsustainable. Medical and technological advancements have given this cohort an achievement award in terms of longer, healthier lives and there is a choice to make. Either substantive changes to redefine this life stage are made or the salutary lesson afforded by the new longevity could be squandered. (shrink)

Intentional, ‘commonsense,’ or ‘folk’ psychology is, as Jerry Fodor has remarked, ubiquitous. Explanations of what we say and do in terms of our reasons for acting are the stock in trade of intentional psychology. But there is a question whether explanations in terms of reasons are properly explanatory. Donald Davidson and Daniel Dennett, to name two, have defended intentional psychology and its reason‐explanations. Still, many philosophers – including Fodor, Davidson and Dennett – fail to pay due attention to the narrative (...) basis of such agent‐centered accounts of action. In this paper, I argue that psychological explanation is an agent‐centered, narrative‐based interpretive practice. To make my case, I present a poetics of psychological explanation: seven elements which collectively describe what makes psychological explanations work. Narrative form allows us to represent the temporal arc of agents’ actions – as well as the temporal arc of their reasoning about their actions, both prospective and retrospective. It allows us to negotiate between the canonical and the exceptional in human experience, and thus to account for actions that strike us as puzzling or unusual – whether the puzzle originates in our suboptimal understanding or the agent's suboptimal reasoning. And it allows us to juxtapose different perspectives on any action. Such juxtapositioning gives us a mechanism for coming to see how an action that strikes us as misguided might have been construed by the agent as reasonable given her understanding of her circumstances. After establishing the seven elements of the poetics, I address the objection that narrative‐based accounts of intentional action are not properly explanatory. (shrink)

Research in animal behavior begins by identifying what animals are doing. In the course of observation, the observer comes to see animals as performing a particular activity. How does this process work? How cn we be certain that behavior is identified correctly? Wittgenstein offers an approach to these questions. looking at the uses of certainly rather than attempting to find rules that guarantee it. Here two stages in research are distinguished: first, watching animals, and second, reporting the results to other (...) scientists. Certainly about what animals are doing, has different uses at each stage. (shrink)

The bias paradox emerges out of a tension between objectivism and relativism.If one rejects a certain the conception objectivity as absolute impartiality and value-neutrality (i.e., if all views are biased), how, then, can one hold that some epistemic perspectives are better than others? This is a problem that has been most explicitly dealt with in feminist epistemology, but it is not unique to feminist perspectives. In this paper, I wish to clearly lay out the nature of the paradox and the (...) various attempts to avoid it. I also intend to show why it is a problem for any epistemological view that rejects absolute objectivity. Finally, I wish to briefly outline a possible solution to the paradox, a solution that requires recognizing that rationality necessarily requires both objective and subjective elements. (shrink)

When should listening through observation stand alone? --.

Feminist philosophers are often concerned with rejecting Cartesian notions of objectivity which eliminate all subjectivity on the part of knowers. However, this rejection of a notion of pure (non-subjective) neutrality has led the dilemma that Louise Antony calls the “bias paradox” (Antony 1993, 188-90). At the heart of this paradox lies the seeming choice between objectivism and relativism. It has two fundamental commitments that clearly focus this dilemma: (1) the explicit rejection of the concept of impartial objectivity and (2) the (...) desire to assert the reality of women’s oppression. The problem is that in the absence of impartiality (at least as an ideal), there appears to be a lack of principled, normative criteria for evaluating beliefs across differing epistemic perspectives. While this tension is dealt with most straightforwardly in discussions of naturalized feminist epistemology and feminist philosophy of science, the bias paradox, nonetheless, is not merely a problem for feminists. Any view that rejects the Cartesian ideals of pure objectivity and value-neutrality will ultimately be forced to confront the dilemma that seemingly results from the paradox; namely, to either endorse pure impartiality or accept an “anything goes” relativism. (shrink)

In The Virtue of Feminist Rationality the author develops a specifically feminist account of rationality, an account which treats reason as a virtue concept. Contrary to some feminists claims that reason is inherently and irredeemably masculine, Heikes argues that the coherence of feminism demands a rational ground and that feminists must be willing to challenge the masculine connotations that have been historically linked to reason. While acknowledging contemporary philosophy’s vehement rejections of Enlightenment accounts of rationality, the author develops an understanding (...) of rationality that relies on premodern roots that circumscribe the concept much less narrowly. As Heikes argues, a virtue account of rationality not only rejects many of what feminists hold to the be most objectionable aspects of philosophical accounts of reason, it is also capable of bridging the divide between several deeply ingrained philosophical dichotomies. Because philosophical dichotomies become most deeply polarized and entrenched during the modern era, the undermining of modern assumptions concerning reason and rationality also undermines the polarizing thinking that has defined rationality for the past several centuries. -/- . (shrink)

When a doctor writes prescriptions in his office, following consultation with a patient, and receives no compensation other than the normal fee for service, can this still be drug trafficking? Recent courtjudgments have emphatically held that it can, but in so doing courts wrongly impose criminal liability on doctors for trusting patients.

Völker Heins, Between Friend and Foe: The Politics of Critical Theory Content Type Journal Article Category Book Review Pages 266-268 Authors Deborah Cook, University of Windsor, 401 Sunset Avenue, Windsor, Ontario, N9B 3P4, Canada Journal Journal of Critical Realism Online ISSN 1572-5138 Print ISSN 1476-7430 Journal Volume Volume 11 Journal Issue Volume 11, Number 2 / 2012.

Feminist philosophy is highly critical of Cartesian, and more broadly Enlightenment, conceptions of rationality. However, feminist philosophers typically fail to address contemporary theories of rationality and to consider how more current thoeories address feminist concerns. I argue that, contrary to their protestations, feminists are “obsessing over an outdated conception of reason” and that even the most suspect of “malestream” philosophers express an understanding of rationality that is closer to feminist concerns than Cartesian ones. I begin by briefly examining key features (...) of Cartesian rationality and discuss how these features are largely rejected by contemporary philosophy and cognitve science. I then discuss how the philosophical accounts of Robert Nozick and Robert Audi refelect this rejection of Cartesian rationality. Finally, I discuss how the views of Nozick and Audi are in line with many feminist concerns, and I argue that feminists need to take seriously some theory of rationality. (shrink)

Resenha do livro: CASANOVA, Marco. Mundo e historicidade: leituras fenomenológicas de Ser e tempo – volume 3: uma estranha introdução. 1.ed. Rio de Janeiro: Via Verita, 2023.

ABSTRACTProfessional associations, once the bodies responsible for professional self-regulation, have lost regulatory power. Some have entered into co-regulatory arrangements with state or independ...